IPCS JOINT SYMPOSIA 8
SGOMSEC 4
SHORT-TERM TOXICITY TESTS FOR
NON-GENOTOXIC EFFECTS
Edited by:
Philippe Bourdeau -- Commission of the European Communities, Brussels, Belgium
Emmanuel Somers - Health and Welfare Canada, Ottawa, Canada
G. Mark Richardson - Health and Welfare Canada, Ottawa, Canada
J. R. Hickman - Health and Welfare Canada, Ottawa, Canada
Prepared by:
Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC)
Published on behalf of the Scientific Committee on Problems of the Environment (SCOPE)
of the International Council of Scientific Unions (ICSU),
and the International Programme on Chemical Safety (IPCS)
of the World Health Organization (WHO),
the United Nations Environment Programme (UNEP),
and the International Labour Organization (ILO)
by:
JOHN WILEY & SONS
Chichester, New York, Brisbane, Toronto, Singapore
Copyright 1990: by the Scientific Committee on Problems of the Environment (SCOPE)
Click on a chapter number to open pdf.
Chapter 1. Introduction, General Conclusions, and Recommedations
Chapter 2. Non-specialized Mammalian Cell Cultures for Toxicity Testing
Chapter 3. Methods to Detect Toxic Effects in Specific Mammalian Organs and Physiological Systems
Chapter 4. Methods to Predict Toxicity
Chapter 5. Short-term Tests in Ecotoxicology
Chapter 6. Conceptual Approaches to Methodology Development - Alan M. Goldberg and Andrew N. Rowan
Chapter 7. Toxicity Tests with Mammalian Cell Cultures - B. Ekwall, V. Silano, A. Paganuzzi-Stammati and F. Zucco
Chapter 8. The Gastrointestinal Tract and Short-term Toxicity Tests - Donald Barltrop and Martin J. Brueton
Chapter 9. Specific Organ/System Toxicity: the Liver - James W. Bridges
Chapter 10. The Developing Kidney in Toxicity Tests - Lauri Saxen
Chapter 11. The Skin: Predictive Value of Short-term Toxicity Tests - Raymond R. Suskind
Chapter 12. Evaluation and Prediction of Chemical Toxicity using Haematopoietic Cell Renewal Systems - T.M. Fliedner, H. Heit and G. Pabst
Chapter 13. Short-term Tests for Neurotoxicity - Silvio Garattini
Chapter 14 . Methods for Assessing the Effects of Chemicals on the Endrocrine System - J.H. Clark and F.X.R. van-Leeuwen
Chapter 15. Methods for Assessing the Effects of Chemicals on the Immune System - J.G. Vos and J.H. Dean
Chapter 16. Potential Short-term Tests to Detect Chemicals Capable of Causing Reproductive and Developmental Dysfunction - Carlton H. Nadolney, Neil Chernoff, Robert L. Dixon, Kundan S. Khera, Ralf Krowke, Boris V. Leonoy, Diether Neubert and Sonia Tabacova
Chapter 17. Toxicological versus Ecotoxicological Testing - Guido Persoone and James Gillett
Chapter 18. Possibilities and Limitations of Predictions from Short-term Tests in the Aquatic Environment - Guido Persoone, David Calamari and Peter Wells
Chapter 19. Possibilities and Limitations of Short-term Tests for Ecotoxicologic Effects: Terrestrial Approaches - James W. Gillett
Chapter 20. Predicting Safe Levels of Chemicals - I.V. Sanockij
Chapter 21. Computer-aided Chemical Structure-handling Techniques in Structure-Activity Relationship Systems - Josef Friedrich, Wolfgang Schubert and Ivar Ugi