Methods to Assess DNA Damage and Repair:

Interspecies Comparisons

Edited by:

Robert G. Tardiff, EA Enginering, Science, & Technology, Inc., Silver Spring, Maryland, USA

Paul H. Lohman, Leiden University, The Netherlands

Gerald N. Wogan, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Prepared by:

Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC)

Published on behalf of the Scientific Committee on Problems of the Environment (SCOPE) of the International Council of Scientific Unions (ICSU), and the International Programme on Chemical Safety (IPCS) of the World Health Organization (WHO), the United Nations Environment Programme (UNEP), and the International Labour Organization (ILO)



Chichester, New York, Brisbane, Toronto, Singapore

Copyright 1994: Scientific Committee on Problems of the Environment

Click on a chapter number to open pdf.

Front Matter


PART 1: Joint Report

Chapter 1. Introduction, General Conclusions, and Recommedations

Chapter 2. DNA Damage

Chapter 3. DNA Repair and Mutagenesis

Chapter 4. DNA Repair, Mutagenesis, and Risk Assessment

PART 2: Contributed Chapters

Chapter 5. DNA Adducts and Their Consequences -- F.A. Beland and M.C. Poirier

Chapter 6. Nucleotide Excision-Repair Among Species -- J.H.J. Hoeijmakers and A.R. Lehman

Chapter 7. Interspecies Determinants: Bioactivation and Inactivation of Carcinogens -- G.J. Mulder

Chapter 8. Monitoring Cytogenetic Damage In Vivo -- A.T. Natarajan, J.D. Tucker, and M.S. Sasaki

Chapter 9. In Vivo Somatic Cell Gene Mutations in Humans -- R.J. Albertini, J.A.Niklas, S.H. Rebison, and J.P. O'Neill

Chapter 10. DNA Repair in Specific Sequences and Genomic Regions -- L.F. Mullenders and C.A. Smith

Chapter 11. Molecular Analysis of Mutations in Endogenous Genes -- H. Vrieling and A.A. van Zeeland

Chapter 12. Molecular Analysis of Mutations in Shuttle Vectors and Transgenic Animals -- M.L. Wood, S.B. Verghis,
and J.M. Essigman

Chapter 13. Structure-Activity Relationships (SAR): Computerized Systems -- M.D. Waters, A.M. Richards, J.R. Rabinowitz,
H.F. Stack, P.D.M. Lohman, and H.S. Rosenkranz

Chapter 14. Structure-Activity Relationships: Experimental Approaches -- E.W. Vogel and J. Ashby